#845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment)

In this episode of The Tim Ferriss Show, Tim Ferriss engages in a detailed discussion with Dr. Dominic D'Agostino, focusing on ketosis, its benefits, and how to effectively implement it. Ferriss shares his personal experiences with ketogenic dieting since the late 90s and his recent month-long experiment using continuous glucose and ketone monitoring to track his health metrics. He shares various benefits he observes from ketosis, including reduced sleep needs, increased mental clarity, and mood stabilization.

Dr. D'Agostino, an expert in metabolic therapies, explains the various reasons one might consider a ketogenic approach, highlighting its potential for weight loss, neuroprotection, and the management of mood and psychiatric disorders. The conversation delves into the implications of exogenous ketones, discussing their popularity, potential toxicity, and how they can affect insulin levels and overall metabolism.

As they navigate the topic of nutritional strategies for entering ketosis, Ferriss and D'Agostino detail the importance of meals, macronutrient ratios, and the challenges that may arise when shifting to a ketogenic diet. They also discuss the role of intermittent fasting and how that may affect a ketogenic lifestyle, debating whether consuming ketogenic meals in the morning is beneficial.

The episode culminates with a consideration of practical applications and real-life anecdotes about the challenges and results of adopting a ketogenic approach. Ferriss provides insights from his own experiments, attesting to the mental and physical benefits of ketosis while encouraging listeners to experiment and find what works best for them.